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In the current research, we documented the identification as well as the characterization of a fresh atypical opioid receptor with exclusive unfavorable regulatory Houses toward opioid peptides.1 Our results confirmed that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can also be a wide-spectrum sca